Cardiovascular Study

What Is Heart Failure

Heart failure is a condition in which the heart cannot pump enough blood to meet the body’s needs. Heart failure symptoms may include the following:

Shortness of breath (SOB) doing everyday activities
SOB during rest or while lying flat
Fatigue and tiredness
Dizziness, confusion, sadness, or depression
Swelling in lower extremities
Weight gain
Abdominal discomfort or swelling
Little or no appetite

Why Participate?

There are currently no device treatment options (and very few overall options) for this kind of heart failure. You can still receive all the traditional therapy you would have from your doctor in addition to being in the trial. Patients in clinical trials have historically done better than their non-study counterparts.

Are You Eligible for the Study?

Has your doctor told you that you have heart failure with ventricular ejection fraction between 40-60%?
Have been hospitalized for heart failure symptoms in the past year?
Do you have heart failure and heart failure symptoms despite taking medication?

Get Started Now!

Don't Worry! You are not committed to participate in a study by completing this form.

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Seela Ramesh, MD

Dr. Ramesh is a board-certified Gastroenterologist with extensive expertise in Advanced and Therapeutic Endoscopy, ERCP, Endoscopic Ultrasonography (EUS), and the management of liver diseases. He completed his medical education at the Medical College of Virginia, an institution globally recognized for its excellence in Gastroenterology and Hepatology.

A highly experienced Principal Investigator, Dr. Ramesh has led numerous clinical trials across a wide range of therapeutic areas, including hepatology, inflammatory bowel disease (IBD), and metabolic liver disorders. His research contributions have helped advance innovative treatments, and he has been published in leading peer-reviewed journals. His work includes studies on hepatitis C, nonalcoholic fatty liver disease (NAFLD), and the role of cannabinoid receptors in hepatic metabolism.

Dr. Ramesh’s publications and presentations include:

Ramesh, S., & Sanyal, A. J. (2004). Hepatitis C and nonalcoholic fatty liver disease. Seminars in Liver Disease, 24(4), 399-413.
Ramesh, S., & Sanyal, A. J. (2005). Evaluation and management of non-alcoholic steatohepatitis. Journal of Hepatology, 42(1), S2-S12.
Ramesh, S., Mirashi, F., Choudhoury, J., & Sanyal, A. J. (2005). Cannabinoids block interferon-mediated suppression of hepatitis C virus replicon. AASLD, Poster Presentation.
Ramesh, S., Mirashi, F., Choudhoury, J., Gupta, S., & Sanyal, A. J. (2005). Methanandamide promotes hepatic lipogenesis by increasing SREBP-1 and SREBP-2 activity—a novel effect of cannabinoid (CB1) receptor activation. AASLD, Poster Presentation.
Qasem, A., Ramesh, S., & Naser, S. A. (2018). Role of TNF antagonists in susceptibility to mycobacterial infection in association with genetic polymorphisms in Crohn's disease. UCD Biomedical Sciences Annual Graduate Research Symposium, Poster Presentation.

Dr. Ramesh is a Clinical Assistant Professor of Medicine at the University of Central Florida and plays an active role in training medical professionals at Osceola Regional Medical Center. He is also a distinguished member of professional organizations, including the American Gastroenterological Association (AGA), the American Society for Gastrointestinal Endoscopy (ASGE), the American Association for the Study of Liver Diseases (AASLD), and the Crohn’s & Colitis Foundation (CCF).

With a strong background in clinical research, protocol development, and investigational therapies, Dr. Ramesh is dedicated to advancing medical knowledge and improving patient outcomes through innovative clinical trials.